Tumour associated macrophages

tumour infiltrating lymphocytes : apoptotic and mitotic cells in human colorectal cancer.

by Catherine Ann Higgins

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Published 1998 by The Author] in [S.l .
Written in English

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Edition Notes

Thesis (D. Phil.) - University of Ulster, 1998.

ID Numbers
Open Library	OL18546767M

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• Tumour-associated macrophages (TAMs) are a key component of the cancer microenvironment, and influence tumour growth and progression • TAMs can have a dual supportive and inhibitory. Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells present in the tumor microenvironment (TME).Cited by:

A large body of literature supports the fact that monocytes and macrophages associated with established tumours also show an immunosuppressive, M2 phenotype,,. TAMs have decreased ability to present tumour-associated antigens, lyse tumour cells, and stimulate the anti-tumour functions of T-cells and NK by:   Nanovehicles, due to their specific physicochemical properties, are emerging as key translational moieties in tackling tumor‐promoting, M2‐like tumor‐associated macrophages (TAMs). Cancer immuno‐nanomedicines target TAMs primarily by blocking M2‐like TAM survival or affecting their signaling cascades, restricting macrophage Cited by: Tumor-associated macrophages (TAMs) are thought to acquire an M2 phenotype, contributing to tumor growth and progression. Some tumors can also produce factors, including M-CSF/CSF1, MCP-1/CCL2 and Angiotensin II, that trigger the amplification and mobilization of macrophages in on: Phagocytosis.

This knowledge has motivated the development of agents that target tumour‐associated macrophages (TAMs), some of which have been investigated in early clinical trials. Here, we provide a comprehensive overview of the biology and therapeutic targeting of TAMs, highlighting opportunities, setbacks, and new challenges that have emerged after a Author: Tim Beltraminelli, Michele De Palma. Purchase Cancer Immunotherapy - 2nd Edition. Print Book & E-Book. ISBN , ROLE OF TUMOUR-ASSOCIATED MACROPHAGES IN CANCER-RELATED INFLAMMATION A. Sica1,2,* 1Istituto Clinico Humanitas IRCCS, via Manz Rozzano, Italy 2DiSCAFF, University of Piemonte Orientale A. Avogadro, via Bovio 6, Novara, Italy The construction of an inflammatory microenvironment provides the fuel for cancer development and Missing: book.